反应详情

温度

-15 °C

A nitrating solution consisting of 2.2 ml of nitric acid and 24 ml of sulphuric acid is pre-cooled to -15° C. 9.26 g of 3-(4-chloro-2-fluorophenyl)-6 -trifluoromethyl-2,4(1H,3H)-pyrimidinedione are added portion wise to the solution while stirring. The mixture is stirred at 15° C. for 30 minutes and subsequently at room temperature for 1 hour. Thereafter, the mixture is poured onto 150 ml of ice-water and the resulting crystalline precipitate is filtered off. In this manner there is obtained 3-(4-chloro-2-fluoro-5-nitrophenyl)-6 -trifluoromethyl-2,4(1H,3H)-pyrimidinedione. m.p. 204° C.

1. stirringThe mixture is stirred at 15° C. for 30 minutes and subsequently at room temperature for 1 hour
2. filtrationthe resulting crystalline precipitate is filtered off