Boron trifluoride etherate → HCID 20025903, compound

Participants

Reaction Conditions

Reaction Steps

4.24 g of boron trifluoride etherate and 6.75 g of 3-(5-amino-4-chloro-2-fluorophenyl)-1 -methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione are placed at -15° C. in 50 ml of methylene chloride. A solution of 3.2 ml of isopentyl nitrite in 20 ml of methylene chloride is added dropwise to the mixture within 20 minutes while cooling. The mixture is subsequently stirred at 5° C. for 45 minutes, 25 treated with 50 ml of n-pentane and the resulting crystals are filtered off. There is obtained 2-chloro-5-[3,6-dihydro-2,6-dioxo -3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzenediazonium tetrafluoroborate. m.p. 191° C. (decomposition).

Provenance & Evidence