Ethylene Glycol → HCID 70392094, compound

Participants

Reaction Steps

38.2 g (0.129 mol) of ethyl 2,6-dimethyl-4-thiomorpholinylpyridine-3-carboxylate 1-oxide(see Table 1, Example 19), 10.6 g (0.189 mol) of solid potassium hydroxide and 100 ml of ethylene glycol were heated at 170° C. for 5 hours. The mixture was then diluted with water, neutralized with 6 N hydrochloric acid, and the water and ethylene glycol were removed by distillation under reduced pressure. The residue was taken up in ethanol, insolubles were removed by filtration, and the solution was boiled with active charcoal, filtered once more and ethanolic HCl was added. The mixture was evaporated to dryness, and the hydrochloride was recrystallized from methanol.

Provenance & Evidence