反应详情

To a stirred mixture of 50 ml of water, 50 ml of ether and 10.0 g of 4-sec-butylphenol was added dropwise, 7.5 ml of 61% nitric acid was added dropwise while cooling with ice. After, the temperature of the mixture was raised to room temperature and the reaction was continued for 4 days. The reaction mixture was extracted with 300 ml of ethyl acetate, washed with a brine and dried with anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away. The residue was purified by subjecting to silica-gel column-chromatography [eluent:chloroform] to give 14.71 g of 4-sec-butyl-2-nitrophenol.

1. additionwas added dropwise
2. temperaturewhile cooling with ice
3. extractionThe reaction mixture was extracted with 300 ml of ethyl acetate
4. washwashed with a brine
5. dry with materialdried with anhydrous sodium sulfate
6. filtrationThe drying agent was filtered off
7. distillationthe solvent was distilled away
8. customThe residue was purified