Nitric Acid → HCID 15036315, compound

Participants

Reaction Steps

To a stirred mixture of 50 ml of water, 50 ml of ether and 4-cyclopentylphenol was added dropwise 2.1 ml of 61% nitric acid and further was added a catalytic amount of sodium nitrite, then the mixture was reacted with stirring at room tempeature for 5 days. The reaction mixture was extracted with 200 ml of ethyl acetate and dried wih anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away under reduced pressure. The residue was purified by subjecting to silica-gel column-chromatography [eluent:chloroform-n-hexane (1:1)] to give 3.60 g of 4-cyclopentyl-2-nitrophenol.

Provenance & Evidence