Potassium Carbonate → 1-[5-Chloro-2-(phenylmethyl)phenyl]piperazine hydrochloride

Participants

Reaction Steps

18.18 g of 2-benzyl-5-chloroaniline, 14.90 g of bis-(2-chloroethylamine)hydrochloride in 65 ml of n-butanol and repeated additions of 5.78 g of anhydrous potassium carbonate are reacted according to the method described in Ex. 1. The hydrochloride is formed in methylene chloride and a precipitate forms by adding ethyl ether; it is then filtered, washed repeatedly with ethyl ether and dried to give 17 g of hygroscopic product. 8.4 g (25%) of a whitish solid, m.p. 256°-258° C., chromatographically pure and elemental analysis correct are isolated by recrystallization from ethanol.

Provenance & Evidence