m-Chloroperbenzoic acid → HCID 14372495, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5 ml. of tetrahydrofuran containing 170 mg. (0.71 mmol) of 8-(2-pyrimidylthio)quinoline was added 300 mg. of sodium bicarbonate and the mixture cooled to 0° C. m-Chloroperbenzoic acid (85%, 153 mg., 1.0 molar equivalent) in 5 ml. of the same solvent was added dropwise. After the addition was complete the reaction was allowed to warm to 25° C. and was stirred overnight. The reaction mixture was poured into a sodium bicarbonate solution and the product extracted with ethyl acetate. The organic layer was separated, dried over sodium sulfate and concentrated in vacuo. The residue was triturated with a small amount of ethyl acetate and filtered to yield title product, 84 mg., m.p. 152°-155° C.

Provenance & Evidence