Potassium Carbonate → 4-(4-Hydroxyphenyl)-1-(3,4-dihydro-3-methyl-2-phenylpyrimidin-4-on-6-ylmethyl)piperazine

関与物質

反応手順

According to the same procedure as described in Example 20, starting from 3.39 g (19 mmol) of 1-(4-hydroxyphenyl)piperazine and 4.20 g (17.9 mmol) of 6-chloromethyl-3,4dihydro-3-methyl-2-phenylpyrimidin-4-one, using 1.24 g (9 mmol) of K2CO3, 4.42 g (=65.6% yield) of 4-(4-hydroxyphenyl)-1-(3,4-dihydro-3-methyl-2-phenylpyrimidin-4-on-6-ylmethyl)piperazine were obtained; melting point 206°-207° C., analysis: C22H24N4O2 (MW 376.46) calc. C 70.19 H6.43 , N 14.88; found C 69.2, H 6.4, N 14.5%. For workup of the reaction mixture, the DMF had been evaporated off in vacuo, the residue had been taken up in water/CH2Cl2 and neutralized, and the CH2Cl2 extract residue had been crystallized from CH3OH.

情報源と証拠