Dimethylcarbamoyl Chloride → HCID 14231157, compound

Participants

Reaction Steps

A solution containing 4-methylimidazole (17.0 g, 0.25 mole), N,N-dimethylcarbamoyl chloride (27.0 g, 0.25 mole) and triethylamine (30 g, 0.30 mole) in acetonitrile (125 mL) is stirred at reflux for 20 hours. The reaction mixture is cooled, diluted with ether (1000 mL) and filtered. The filtrate is evaporated and the residue is distilled under reduced pressure to afford 1-dimethylcarbamoyl-4-methyl-imidazole, b.p. 104°-106° C./0.35 mm Hg.

Provenance & Evidence