Sodium Hydroxide → HCID 54179635, compound

Participants

Reaction Steps

6.00 g (17.8 mmol) of the ester was dissolved in 120 ml of methanol. To the resulting solution was added 30 ml of an aqueous solution containing 3.60 g of sodium hydroxide at room temperature. The mixture was left to stand at room temperature overnight. Methanol was distilled off from the reaction mixture under reduced pressure and the residue was made acidic with hydrochloric acid under ice cooling. The mixture was extracted three times with chloroform. The extract organic layer was washed with water and subsequently dried over anhydrous sodium sulfate. The solvent was distilled off from the extract under reduced pressure to afford 4.320 g (15.5 mmol) of 5-(3-methoxy-4-ethoxymethoxyphenyl)-2,4-pentadienoic acid.

Provenance & Evidence