Cyclohexaneacetic acid → Cyclohexylacetyl chloride

HRID 1723083Notes

Reaction equation

HRID 1723083 reaction equation
[CH:1]1([CH2:7][C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:13]>>[CH:1]1([CH2:7][C:8]([Cl:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21363Cyclohexaneacetic acidHCID 24386Thionyl Chloride

Product 1

HCID 2757989Cyclohexylacetyl chloride

Procedure

Cyclohexyl acetic acid (2.5 g; 0.02 moles) was mixed with SOCl2 (3.7 cc; 0.05 moles) and the resulting solution was kept at 80° C. for 1.5 hours. The mixture was concentrated under vacuum and some washings were carried out with anhydrous toluene to remove SOCl2. The mixture was then dried under vacuum and the title product was obtained as a raw material which was used as such in the next step (b).

Workup

  1. concentrationThe mixture was concentrated under vacuum
  2. customto remove SOCl2
  3. customThe mixture was then dried under vacuum

Sources & evidence

ORD record
ord-ded1b88e64ef40989f3e50b837c224f8
Source dataset
uspto-grants-1989_08
Patent number
US04859698

Reaction notes

Loading…