Ethanol → HCID 14518380, compound

Participants

Reaction Steps

(a-4) To a stirred soluiton of 0.92 parts of sodium in 32 parts of ethanol were added 5.46 parts of ethyl 1-hydroxy-6-(hydroxymethyl)-1H-benzimidazole-2-carboxylate monohydrochloride. The whole was stirred for 10 minutes and concentrated. 18 Parts of methylbenzene were added and the mixture was evaporated. 13.5 Parts of N,N-dimethylformamide and a solution of 2.84 parts of iodomethane in 4.5 parts of N,N-dimethylformamide were added. After stirring for 30 minutes, the reaction mixture was evaporated. The residue was purified by column chromatography over silica gel using a mixture of trichloromethane and acetonitrile (80:20 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was crystallized from a mixture of 2-propanol and 2,2'-oxybispropane (1:4 by volume). The product was filtered off and dried, yielding 2.5 parts (50%) of ethyl 6-(hydroxymethyl)-1-methoxy-1H-benzimidazole-2-carboxylate; mp. 110.1° C. (int. 32).

Provenance & Evidence