Ethanimidic acid, ethyl ester, hydrochloride (1:1) → HCID 178432215, compound

Participants

Reaction Steps

(a-1) A mixture of 20 parts of (3,4-diaminophenyl) (3-fluorophenyl) methanone, 27 parts of ethyl ethanimidate hydrochloride and 80 parts of methanol was stirred for 17 hours at reflux temperature. The reaction mixture was filtered and the filtrate was evaporated. The residue was taken up in a potassium carbonate solution 10% and the product was extracted with ethyl acetate. The extract was dried, filtered and evaporated. The residue was purified by column chromatography over silica gel using a mixture of dichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 15.6 parts (70.5%) of 3-fluorophenyl) (2-methyl-1H-benzimidazol-5-yl)methanone as a residue (int. 34).

Provenance & Evidence