Sulfuric Acid → HCID 14518424, compound

Participants

Reaction Steps

(a-3) To a stirred and cooled (0° C.) mixture of 21.5 parts of N-[4-[1-(1H-imidazol-1-yl)-2-methylpropyl]phenyl]acetamide and 183 parts of concentrated sulfuric acid were added portionwise 8.6 parts of potassium nitrate at 0°~5° C. The reaction mixture was poured into ice water and treated with ammonium hydroxide. The product was extracted three times with 150 parts of trichloromethane. The combined extracts were dried, filtered and evaporated, yielding 20 parts (80%) of N-[4-[1(1H-imidazol-1-yl)-2-methylpropyl]-2-nitrophenyl]acetamide as a residue (int. 103).

Provenance & Evidence