反应详情

(a-4) A mixture of 1.45 parts of 4-[(1H-imidazol-1-yl)phenylmethyl]-2-nitrobenzenamine, 0.78 parts of acetyl chloride and 25 parts of acetic acid was stirred over weekend at room temperature. The methanol layer was removed in vacuo and the residue was taken up in water and dichloromethane. After treatment with ammonium hydroxide, the dichloromethane layer was dried, filtered and evaporated, yielding 1.6 parts (95%) of N-[4-[(1H-imidazol-1-yl)phenylmethyl]-2-nitrophenyl]-acetamide as a residue (int. 127).

1. customThe methanol layer was removed in vacuo
2. dry with materialAfter treatment with ammonium hydroxide, the dichloromethane layer was dried
3. filtrationfiltered
4. customevaporated