Hydrochloric Acid → HCID 178432164, compound

Participants

Reaction Steps

A mixture of 7.4 parts of N-[2-amino-4-[1-(1H-imidazol-1-yl)ethyl]phenyl]acetamide, 10 parts of acetic acid and 100 parts of a hydrochloric acid solution 4N was stirred and refluxed for 3.5 hours. The reaction mixture was evaporated. The residue was dissolved in 20 parts of 2-propanol. The product was crystallized at room temperature. The product was filtered off and dried, yielding 8.1 parts (90.2%) of 5-[1-(1H-imidazol-1-yl)ethyl]-2-methyl-1H-benzimidazole dihydrochloride; mp. 236.2° C. (compound 206).

Provenance & Evidence