Sodium Hydroxide → HCID 14518708, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 13.2 parts of 1-[(4-fluoro-3-nitrophenyl)methyl]-1H-imidazole, 13 parts of 4-pyridinemethanamine and 80 parts of ethanol was stirred for 6 hours at 60° C. 14.5 Parts of sodium hydroxide were added and the whole was stirred for 30 minutes at 60° C. The reaction mixture was evaporated. The residue was dissolved in 100 parts of water. Hydrochloric acid was added dropwise till a pH between 6 and 7 was reached. The product was filtered off, washed with water and 2-propanol and crystallized from 80 parts of 2-propanol. The product was filtered off and dried, yielding 10.7 parts (61%) of 6-(1H-imidazol-1-ylmethyl)-2-(4-pyridinyl)-1H-benzimidazol-1-ol; mp. 198.1° C. (compound 209).

Provenance & Evidence