反应详情

A mixture of 5.28 parts of 4-[(1H-imidazol-1-yl)phenylmethyl]-1,2-benzenediamine, 2.3 parts of carbon disulfide, 80 parts of ethanol, 1.68 parts of potassium hydroxide and 11 parts of water was stirred for 3 hours at reflux temperature. After evaporation, 100 parts of water were added to the residue and the mixture was neutralized with 1.8 parts of a 0.03M acetic acid solution. After stirring, the precipitated product was filtered off, washed with 2-propanone and dried, yielding 4.3 parts (70.1%) of 5-[(1H-imidazol-1-yl)phenylmethyl]-1H-benzimidazole-2-thiol; mp. 260.1° C. (compound 225).

1. temperatureat reflux temperature
2. customAfter evaporation, 100 parts of water
3. additionwere added to the residue
4. stirringAfter stirring
5. filtrationthe precipitated product was filtered off
6. washwashed with 2-propanone
7. customdried