Imidazole → HCID 178420757, compound

Participants

Reaction Steps

A mixture of 4.4 parts of 1H-imidazole and 5 parts of 2-chloro-5-(1H-imidazol-1-ylmethyl)-1H-benzimidazole was molten together for 1 hour at 140° C. The sticky mixture was taken up in a mixture of ethanol and potassium carbonate. The supernatant liquid was decanted and evaporated to dry. The residue was purified by column chromatography over silica gel using a mixture of trichloromethane, methanol and ammonium hydroxide (90:10:0.1 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was taken up in 15 parts of water. The product was filtered off and crystallized from a mixture of methanol and ethyl acetate, yielding 0.95 parts (17%) of 2-(1H-imidazol-1-yl)-5-(1H-imidazol-1-ylmethyl)-1H-benzimidazole; mp. 226.2° C. (compound 258).

Provenance & Evidence