Thionyl Chloride → HCID 19838006, compound

HRID 1723185Notes

Reaction equation

HRID 1723185 reaction equation
S(Cl)([Cl:3])=O.[O:5]=[C:6]1[C:10]([CH2:14][C:15](O)=[O:16])([CH2:11][CH2:12][CH3:13])[C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]=2[O:7]1>C1C=CC=CC=1>[O:5]=[C:6]1[C:10]([CH2:14][C:15]([Cl:3])=[O:16])([CH2:11][CH2:12][CH3:13])[C:9]2[CH:18]=[CH:19][CH:20]=[CH:21][C:8]=2[O:7]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19838010HCID 19838010, compound

Product 1

HCID 19838006HCID 19838006, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

23.7 g of double-distilled thionyl chloride are added dropwise to a solution, stirred and heated to 70° C., of 23.4 g of (2,3-dihydro-2-oxo-3-propyl-3-benzofuranyl)acetic acid in 250 ml of anhydrous benzene. When the addition is complete, the mixture is heated until the evolution of gas has completely ceased. The medium is concentrated under vacuum, the residue washed with 200 ml of anhydrous benzene and the solvent evaporated off. This operation is repeated twice, and a very thick oil which does not crystallize is obtained.

Workup

  1. additionWhen the addition
  2. temperaturethe mixture is heated until the evolution of gas
  3. concentrationThe medium is concentrated under vacuum
  4. washthe residue washed with 200 ml of anhydrous benzene
  5. customthe solvent evaporated off
  6. customa very thick oil which does not crystallize
  7. customis obtained

Sources & evidence

ORD record
ord-e0d131f82781414aa176f0f8b9aeaa3b
Source dataset
uspto-grants-1989_08
Patent number
US04859700

Reaction notes

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