Maleic Acid → HCID 67885874, compound

HRID 1723302Notes

Reaction equation

HRID 1723302 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH2:11][CH2:10][CH:9]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[C:8](=[O:22])[C:7]2=1.[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27]>C(O)C>[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27].[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH2:11][CH2:10][CH:9]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[C:8](=[O:22])[C:7]2=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 19769824HCID 19769824, compound

Product 1

HCID 67885874HCID 67885874, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

8-Fluoro-1,2,3,9-tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-4H-carbazol-4-one (330 mg) was dissolved in dry ethanol (20 ml). Maleic acid (129 mg) in ethanol (10 ml) was added, and the solution was evaporated in vacuo. The residue was triturated with ether and the resultant solid was crystallised from ethanol:ether to give the title compound (351 mg), m.p. 174°-177°.

Workup

  1. customthe solution was evaporated in vacuo
  2. customThe residue was triturated with ether
  3. customthe resultant solid was crystallised from ethanol

Sources & evidence

ORD record
ord-4ed9546473604b049cfb65ab8f2ff2b4
Source dataset
uspto-grants-1989_08
Patent number
US04859662

Reaction notes

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