HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropyl Ether → Ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropyl Ether | HCID 7914 | — |
| Edukt | 3-Fluorophenyl isothiocyanate | HCID 9834 | — |
| Edukt | 1-Piperidinecarboxylic acid, 4-(methylamino)-, ethyl ester | HCID 11063140 | — |
| Produkt | Ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate | HCID 15725103 | 90% |
Reaktionsschritte
To a stirred solution of 91 parts of ethyl 4-(methylamino)-1-piperidinecarboxylate in 420 parts of 2,2'-oxybispropane were added dropwise 75 parts of 1-fluoro-3-isothiocyanatobenzene. Upon completion, stirring was continued for 1 hour. The precipitated product was filtered off and dried, yielding 150 parts (90%) of ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate; mp. 175.2° C. (17).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04861785 |
| Quelldatensatz | uspto-grants-1989_08 |
| ORD ID | ord-94a5f999dc9146a187c902698a289ccd |
| Quellennotiz | uspto-grants-1989_08 |