Dichloromethane → HCID 54464663, compound

Participants

Reaction Steps

There was dissolved 1 g of (3R,4R)-1-tert-butyldimethylsilyl-3-[(R)-1-tert-butyldimethylsilyloxyethyl]-4-trimethylsilyloxyazetidin-2-one into 10 ml of methylene chloride, thereto 0.85 g of dimethylaminopyridine and 0.71 g of acetic anhydride were added and the mixture was reacted for one day at 0° C. After the reaction mixture was diluted with hexane and washed successively with 5% aqueous solution of NaHCO3, an aqueous solution of hydrochloric acid of pH 4 and saturated solution of salt, the resultant was dried with magnesium sulfate and the solvent was distilled away to give 0.85 of a liquid crude product. The obtained liquid was purified by a silica-gel column chromatography (hexane:ether=30:1) to give 0.40 g of (3R,4R)-4-acetoxy-1-tert-butyldimethylsilyl)-3-[(R)-1-tert-butyldimethylsilyloxyethyl)azetidin-2-one as a colorless liquid.

Provenance & Evidence