HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroisoquinoline → 3,4-Dihydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3,4-Dihydroisoquinoline | HCID 76705 | 93.1% |
Reaction Steps
30.0 g of 1,2,3,4-tetrahydroisoquinoline and 15.0 g of sulphur powder in 200 ml of toluene are refluxed for 7 hours. After cooling the sulphur is filtered off, the filtrate is evaporated in vacuo. The resulting thick oily residue is distilled in vacuo. 27.5 g of 3,4-dihydroisoquinoline are obtained, b.p. 64°-67° C. at 0.6 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04861888 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-6234181c243343e593863b276e6b7280 |
| Source note | uspto-grants-1989_08 |