HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroisoquinoline → 3,4-Dihydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3,4-Dihydroisoquinoline | HCID 76705 | 96.5% |
Reaction Steps
6.0 g of 1,2,3,4-tetrahydroisoquinoline and 3.0 g of sulphur powder in 40 ml of dioxane are refluxed for 20 hours. The reaction mixture is evaporated, to the residue 60 ml of ether are added, the precipitated sulphur is filtered off and the filtrate is evaporated. 5.7 g of 3,4-dihydroisoquinoline are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04861888 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-11019ce9aea749659fef7ae33efcb99d |
| Source note | uspto-grants-1989_08 |