Imidazole → HCID 18435651, compound

HRID 1723504Notes

Reaction equation

HRID 1723504 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1/[CH:12]=[CH:13]/[C:14]1[O:15][C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[N:18]=1.[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1>>[N:23]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2/[CH:12]=[CH:13]/[C:14]2[O:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH:27]=[CH:26][N:25]=[CH:24]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 20025807HCID 20025807, compound

Product 1

HCID 18435651HCID 18435651, compound

Procedure

The title compound was prepared by the procedure of Example 1 starting with (A) of Example 1 (8.0 g, 25 mmol) and using imidazole in place of dibutylamine to produce 2.1 g (24% yield) of the free base of the title compound which was converted to the HCl salt, mp 158°-159° C. IR(KBr): 3400, 1600 cm-1. MS: 346(MH+). 1H NMR (CD3OD): δ 9.09 (s, 1H), 7.82-6.81 (m, 12H), 4.51 (t, J=5.4 Hz, 2H), 4.08 (t, J=5.1 Hz, 2H), 2.41 (m, 2H).

Sources & evidence

ORD record
ord-e6a02c105a404939b46c9679e6cdda00
Source dataset
uspto-grants-1989_08
Patent number
US04861897

Reaction notes

Loading…