Dipropylamine → HCID 18435660, compound

HRID 1723505Notes

Reaction equation

Cl[CH:2]([CH3:23])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1/[CH:12]=[CH:13]/[C:14]1[O:15][C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[N:18]=1.[CH2:24]([NH:27][CH2:28][CH2:29][CH3:30])[CH2:25][CH3:26]>>[CH2:24]([N:27]([CH2:28][CH2:29][CH3:30])[CH:2]([CH3:23])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1/[CH:12]=[CH:13]/[C:14]1[O:15][C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[N:18]=1)[CH2:25][CH3:26]

Participants

Reactant 2

HCID 8902Dipropylamine

HCID 20025809HCID 20025809, compound

Product 1

HCID 18435660HCID 18435660, compound

Procedure

The title compound was prepared as described in Example 1 starting with (B) of this Example (3.0 g, 9.2 mmol) and using dipropylamine in place of dibutylamine to produce 0.61 g (17% yield) of the free base of the title compound which was converted to the HCl salt, mp 152°-153° C. IR(KBr): 1600 cm-1. MS: 393(MH+). 1H NMR (CDCl3): δ 8.24-6.97 (m, 10H), 4.08 (t, J=5.2 Hz, 2H), 3.18 (m, 6H), 1.98 (m, 8H), 0.99 (m, 6H).

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-e23b5970fd734cf982d2a2b5f345f4ce
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04861897

Reaction notes

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