2-Methylbenzoxazole → Benzoxazole

Participants

Reaction Steps

To a solution of this product (8.0 g, 35 mmol) and 2-methylbenzoxazole (4.5 ml, 35 mmol) in DMSO (35 ml) was added a 50% aqueous sodium hydroxide solution (15 ml) and worked up as in Example 8 to give (E)-2-[2-(3,5-dimethyl)-4-chloropropoxyphenyl)ethenyl]benzoxazole as a solid (8.2 g, 70% yield). 1H NMR (CDCl3): δ 7.81-6.88 (m, 8H), 4.01 (t, 2H), 3.66 (t, 2H), 2.31 (s, 6H), 2.00 (m, 2H).

Provenance & Evidence