HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 54147595, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-2-fluoroanisole | HCID 75378 | — |
| Reactant | 2H-Indol-2-one, 3-[(dimethylamino)methylene]-1,3-dihydro-, (Z)- | HCID 3028974 | — |
| Solvent | Diethylether pentane | HCID 21877078 | — |
| Product | HCID 54147595 | HCID 54147595 | — |
Reaction Steps
By the procedure of Example C1, without chromatography, but directly crystallizing the crude product from ether/pentane, 3-(dimethylaminomethylene)-2(1H,3H)-indolone (3.77 g, 20 mmoles) and 4-bromo-2-fluoroanisole (4.10 g, 20 mmoles) with NaH (0.96 g of 50% dispersion in oil, 20 mmoles) and Cu2Br2 (5.74 g, 20 mmoles), were converted to title product, 0.79 g, m.p. 113°-114°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04861880 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-d51cad475d13419ea2ddf4480faeaafc |
| Source note | uspto-grants-1989_08 |