HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(1-Pyridinio)methyl-3-cephem-4-carboxylic acid chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7beta-[2-(2-Aminothiazol-4-yl)-2-(cyclopropyloxyimino)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate | HCID 131716059 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(1-Pyridinio)methyl-3-cephem-4-carboxylic acid chloride hydrochloride | HCID 131716082 | — |
Reaction Steps
To a solution of 7β-[2-(2-aminothiazol-4-yl)-2-(cyclopropyloxyimino)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate (syn isomer) (750 mg) in water (50 ml) was added concentrated hydrochloric acid (0.265 ml). The solution was lyophilized to give 7β-[2-(2-aminothiazol-4-yl)-2-cyclopropyloxyimino)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylic acid chloride hydrochloride (syn isomer) (874 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04861769 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-3b20efe488a44b47a1e89834ccb3bf1a |
| Source note | uspto-grants-1989_08 |