Sodium Hydroxide → HCID 178454037, compound

HRID 1723622Notes

Reaction equation

HRID 1723622 reaction equation
[OH-].[Na+].[C:3]([O:7][C:8](=[O:25])[NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([NH:16][C:17]([NH:19]C(OCC)=O)=[S:18])[CH2:12][CH2:11]1)([CH3:6])([CH3:5])[CH3:4]>O.CCO>[C:3]([O:7][C:8](=[O:25])[NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([NH:16][C:17]([NH2:19])=[S:18])[CH2:12][CH2:11]1)([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 178473562HCID 178473562, compound

Product 1

HCID 178454037HCID 178454037, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

7.4 ml of 4M NaOH are added to a suspension of 1.69 g of [trans-4-(3-ethoxycarbonyl-thioureido)cyclohexyl]carbamic acid tert-butyl ester in 10 ml of H2O and 15 ml of EtOH. The mixture obtained is kept at 90° for 30 minutes at RT. The precipitate formed is filtered and washed with diethylether. (trans-4-Thioureido-cyclohexyl)-carbamic acid tert-butyl ester is obtained.

Workup

  1. customThe mixture obtained
  2. customThe precipitate formed
  3. filtrationis filtered
  4. washwashed with diethylether

Sources & evidence

ORD record
ord-6b9eff78a38a418fb8f6b9ea9abca057
Source dataset
uspto-grants-2009_02
Patent number
US07485632B2

Reaction notes

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