HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 57559159, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]- | HCID 12440708 | — |
| Reactant | 5-Methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-benzoic acid | HCID 21100312 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57559159 | HCID 57559159 | — |
Reaction Steps
To a solution of 0.17 mmol 5-methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-benzoic acid in 0.75 ml dimethylformamide, 0.19 mmol TBTU, 0.855 mmol N-ethyldiisopropylamine and 0.205 mmol 4-(4-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine were successively added. The reaction was then stirred at RT for 45 min., concentrated in vacuo and purified by column chromatography (SiO2, 10 g, heptane, ethylacetate 0 to 100%), to give the title compound. MS (m/e): 508.6 (MH+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07485637B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-a34d60c3c9974d9c9c4c246be92744d3 |
| Source note | uspto-grants-2009_02 |