HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 6-(N'-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester | HCID 86598597 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-Chlorophenylamino)-5,6-difluoro-1,2-dihydroindazol-3-one | HCID 67403307 | — |
Reaction Steps
6-(N′-tert-Butoxycarbonylhydrazino)-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester (1.00 equivalent) is treated with a 1:1 mixture of methylene chloride and TFA and stirred for 2 hours The reaction mixture is concentrated under reduced pressure and the product is purified by trituration or flash column chromatography if needed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07485643B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-f465b05b652b48fc9d63acece16c8913 |
| Source note | uspto-grants-2009_02 |