Diisopropylethylamine → HCID 57559117, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared by the addition of 1-methyl-1-phenyl-1,3,4,9-tetrahydrobeta-carboline (105 mg, 400 μmol), CHCl3 (9 mL), 3,4-difluorobenzoyl chloride (85 mg, 480 μmol), and DIEA (140 μL, 800 μmol) to a 25 mL flask. The solution was allowed to stir at 60° C. under N2 for 17 hours. The reaction solution was concentrated, and the crude sample was chromatographed (SiO2, 100% hexane to 20% EtOAc) to yield 35 mg of title compound; 1H NMR (CDCl3) δ 7.54 (1H, d), 7.48 (2H, d), 7.12-7.32 (9H, m), 4.05 (1H, m), 3.64-3.70 (1H, m), 3.19 (1H, m), 2.96 (1H, m), 2.29 (3H, s); MS (ESI): 403 (MH+).

Provenance & Evidence