Methanol → HCID 86614578, compound

Participants

Reaction Steps

Crude 2-({4-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]piperazin-1-yl}sulfonyl)-1-(tetrahydro-2H-pyran-4-yl)ethanone (3.60 g, 0.008M) was dissolved in DCM (120 ml) and methanol (40 ml) at ambient temperature and sodium borohydride (334 mg, 0.0088 mol) was added. Stirred for 2 hours, added H2O (250 ml) and extracted with DCM. Collected the organic phase, dried over MgSO4, filtered and evaporated to dryness to yield 2-({4-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]piperazin-1-yl}sulfonyl)-1-(tetrahydro-2H-pyran-4-yl)ethanol (3.6 g, 95%).

Provenance & Evidence