Water → HCID 86614579, compound

Participants

Reaction Conditions

Reaction Steps

2-({4-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]piperazin-1-yl}sulfonyl)-1-(tetrahydro-2H-pyran-4-yl)ethanol (3.6 g, 0.008M) was dissolved in DCM (100 ml) and triethylamine (5.58 ml, 0.04 mol) was added. The mixture was cooled to 0° C. and methane sulphonyl chloride (0.94 ml, 0.012M) added with stirring at room temperature overnight. Water was added and the organic phase separated off, dried over MgSO4, filtered and evaporated to dryness to yield 1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-{[(E)-2-(tetrahydro-2H-pyran-4-yl)vinyl]sulfonyl}piperazine. Yield (3.15 g, 86.6%).

Provenance & Evidence