Diethyl Ether → 3-Methanesulfonylmethyl-3-methyl-piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

To a 0° C. stirred solution of Intermediate 55 (0.844 g, 3.68 mmol) in dry CH2Cl2 (25 ml) was added Et3N (0.513 ml, 3.682 mmol) and the reaction was stirred for 15 minutes. Methansulfonyl chloride (0.285 ml, 3.682 mmol) was added dropwise and the reaction was allowed to warm to room temperature overnight with good stirring. The reaction was complete by TLC, and Et2O (100 ml) was added. The mixture was filtered and the filter caked was washed with additional Et2O. The filtrate was then concentrated under reduced pressure. The residue was chromatographed with hexanes/EtOAc (0→25%) to yield 1.05 g (93.1%) of 3-methanesulfonylmethyl-3-methyl-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 56). 1H NMR (400 MHz, CDCl3) δ ppm 1.0 (s, 3H), 1.4 (m, 1H), 1.4 (s, 9H), 1.6 (m, 3H), 3.0 (s, 3H), 3.2 (s, 1H), 3.5 (s, 2H), 4.0 (d, J=2.4 Hz, 2H).

Provenance & Evidence