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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1723898Generated: November 1, 2026

Carvedilol → 2-(2-Methoxyphenoxy)ethyl amine

https://huagongshe.com/reaction/1723898

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarvedilolHCID 2585—
SolventEthanolHCID 702—
SolventWaterHCID 962—
ProductCarvedilolHCID 2585—
Product2-(2-Methoxyphenoxy)ethyl amineHCID 1713005425.4%

Reaction Conditions

Temperature65 °C

Reaction Steps

Carvedilol (40 g) was dissolved in 150 ml of ethanol and 40 ml water. The solution was heated with agitation to 60-70° C. until the solid material was completely dissolved. The solution is then cooled with agitation to 10° C. over a period of 3 hours. After stirring the suspension for an additional 2.75 hours, the product is filtered. Pure Carvedilol Form III (35 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07485663B2
Source datasetuspto-grants-2009_02
ORD IDord-eab85ccbdfb3464f9951bd721d1bcdb5
Source noteuspto-grants-2009_02