4-tert-Butylbenzyl mercaptan → HCID 57558438, compound

HRID 1723967Notes

Reaction equation

HRID 1723967 reaction equation
[CH2:1]([S:3]([C:5]1[O:6][C:7]2[C:12]([C:13](=[O:23])[C:14]=1[CH2:15][O:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1)=[CH:11][CH:10]=[CH:9][CH:8]=2)=O)[CH3:2].[C:24]([C:28]1[CH:35]=[CH:34]C(CS)=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>C(#N)C>[C:24]([C:28]1[CH:35]=[CH:34][C:2]([CH2:1][S:3][C:5]2[O:6][C:7]3[C:12]([C:13](=[O:23])[C:14]=2[CH2:15][O:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)=[CH:11][CH:10]=[CH:9][CH:8]=3)=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 27572524-tert-Butylbenzyl mercaptanHCID 57558444HCID 57558444, compound

Product 1

HCID 57558438HCID 57558438, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Into a 25 mL round bottom flask is introduced 2-ethylsulfinyl-3-((2-tetrahydropyranyloxy)methyl) chromen-4-one (5 g, 14.87 mmol). Acetonitrile is then added to it followed by 4-tertbutylbenzyl mercaptan (74.3 mmol). The reaction mixture is stirred for 10 hours at room temperature after which the solvent is removed in vacuo. The crude residue obtained is purified by silica gel chromatography (ethyl acetate:hexanes) to obtain the product.

Workup

  1. customis removed in vacuo

Sources & evidence

ORD record
ord-c389badb0114492eb5992d7d27c03f86
Source dataset
uspto-grants-2009_02
Patent number
US07485283B2

Reaction notes

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