Ethyl N-methylaminoacetate hydrochloride → HCID 11533840, compound

HRID 1724021Notes

Reaction equation

HRID 1724021 reaction equation
[CH3:1][C:2]1[N:3]([CH2:21][C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25](O)=[O:26])[C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([C:11]([OH:20])([C:16]([F:19])([F:18])[F:17])[C:12]([F:15])([F:14])[F:13])=[CH:6][CH:5]=2.Cl.[CH2:32]([O:34][C:35](=[O:39])[CH2:36][NH:37][CH3:38])[CH3:33]>>[CH2:32]([O:34][C:35](=[O:39])[CH2:36][N:37]([CH3:38])[C:25](=[O:26])[C:24]1[CH:28]=[CH:29][CH:30]=[C:22]([CH2:21][N:3]2[C:4]3[C:9](=[CH:8][C:7]([C:11]([OH:20])([C:12]([F:14])([F:13])[F:15])[C:16]([F:19])([F:18])[F:17])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])[CH:23]=1)[CH3:33]

Participants

3

Reactant 2

HCID 171173Ethyl N-methylaminoacetate hydrochlorideHCID 11590065HCID 11590065, compound

Product 1

HCID 11533840HCID 11533840, compound

Procedure

In analogy to example 34, from 3-[2-methyl-5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-indol-1-ylmethyl]-benzoic acid (example 31) and sarcosine ethylester hydrochloride was prepared (methyl-{3-[2-methyl-5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-indol-1-ylmethyl]-benzolyl}-amino)-acetic acid ethyl ester, colorless solid, MS: 531 (MH+).

Sources & evidence

ORD record
ord-408d3bb287ba4db5b6514575660d4994
Source dataset
uspto-grants-2009_02
Patent number
US07485652B2

Reaction notes

Loading…