HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-benzyl-2-methyl-2,3-dihydro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methylindoline | HCID 23305 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-benzyl-2-methyl-2,3-dihydro-1H-indole | HCID 10513589 | 101.5% |
Reaction Steps
To a solution of 1 g (7.5 mmol) of 2-methyl-2,3-dihydro-1H-indole in anhydrous DMF were added 1.03 g (7.5 mmol) of K2CO3 and then dropwise 0.97 mL (8.0 mmol) of benzylbromide. The mixture was stirred at RT for 3 hrs and then distributed between Et2O and a saturated aqueous solution of NH4Cl. The combined organic phases were dried over Na2SO4 and evaporated to yield 1.7 g (quantitative) of crude 1-benzyl-2-methyl-2,3-dihydro-1H-indole, light blue oil, MS: 224 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07485652B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-7bf7653bb0f34916bd2c847cb2d88868 |
| Source note | uspto-grants-2009_02 |