HRID1724042

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1nc(CCN2c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3CC2C)c(-c2ccccc2)o1

HCID11705752

未命名化合物

HCID15616442

未命名化合物

结构：CC1Cc2cc(C(O)(C(F)(F)F)C(F)(F)F)ccc2N1

HCID23346126

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(CCN2c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3CC2C)c(-c2ccccc2)o1.Cc1oc(-c2ccccc2)nc1CCN1c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2CC1C

HCID21082192

未命名化合物

PROCEDURE

实验过程

In analogy to example 75, from 1,1,1,3,3,3-hexafluoro-2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-propan-2-ol (example 51.1) and 4-(2-bromo-ethyl)-5-methyl-2-phenyl-oxazole was prepared 1,1,1,3,3,3-Hexafluoro-2-{2-methyl-1-[2-(2-methyl-5-phenyl-oxazol-4-yl)-ethyl]-2,3-dihydro-1H-indol-5-yl}-propan-2-ol, MS: 485 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-10f9c4d632dc491fa48c56b915c54dfd
来源数据集: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07485652B2
来源说明: uspto-grants-2009_02

反应 SMILES

[F:1][C:2]([F:20])([F:19])[C:3]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]([CH3:18])[CH2:12]2)([OH:8])[C:4]([F:7])([F:6])[F:5].Br[CH2:22][CH2:23][C:24]1[N:25]=[C:26]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:27][C:28]=1[CH3:29].[F:36][C:37]([F:69])([F:68])[C:38]([C:44]1[CH:45]=[C:46]2[C:50](=[CH:51][CH:52]=1)[N:49]([CH2:53][CH2:54][C:55]1[N:56]=[C:57]([CH3:66])[O:58][C:59]=1[C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1)[CH:48]([CH3:67])[CH2:47]2)([OH:43])[C:39]([F:42])([F:41])[F:40]>>[F:5][C:4]([F:7])([F:6])[C:3]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:22][CH2:23][C:24]1[N:25]=[C:26]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[O:27][C:28]=1[CH3:29])[CH:13]([CH3:18])[CH2:12]2)([OH:8])[C:2]([F:1])([F:19])[F:20].[F:68][C:37]([F:36])([F:69])[C:38]([C:44]1[CH:45]=[C:46]2[C:50](=[CH:51][CH:52]=1)[N:49]([CH2:53][CH2:54][C:55]1[N:56]=[C:57]([CH3:66])[O:58][C:59]=1[C:60]1[CH:61]=[CH:62][CH:63]=[CH:64][CH:65]=1)[CH:48]([CH3:67])[CH2:47]2)([OH:43])[C:39]([F:42])([F:41])[F:40]