Water → HCID 21082202, compound

Participants

Reaction Steps

A solution of 50 mg of 1-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-2-methyl-5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-1H-indole-3-carbaldehyde in 1 mL of THF was treated at 0° C. with 5 mg (0.14 mmol) of LiAlH4 and allowed to reach RT within 1 h. Ice cubes were added and the mixture distributed between Et2O and H2O. Drying of the combined organic phases over Na2SO4 and evaporation of the solvent yielded 36 mg of 2-{1-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-3-hydroxymethyl-2-methyl-1H-indol-5-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol, off white solid, 533 (MH+).

Provenance & Evidence