2-Benzyl-4-chloromethyl-5-methyl-oxazole → 2-[1-(2-benzyl-5-methyl-oxazol-4-ylmethyl)-2-methyl-2,3-dihydro-1H-indol-5-yl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

HRID 1724051Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1724051
[F:1][C:2]([F:20])([F:19])[C:3]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]([CH3:18])[CH2:12]2)([OH:8])[C:4]([F:7])([F:6])[F:5].[CH2:21]([C:28]1[O:29][C:30]([CH3:35])=[C:31]([CH2:33]Cl)[N:32]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.FC(F)(F)C(C1C=C2C(=CC=1)N(CC1N=C(C=CC3C=CC=CC=3)OC=1C)C(C)C2)(O)C(F)(F)F>>[CH2:21]([C:28]1[O:29][C:30]([CH3:35])=[C:31]([CH2:33][N:14]2[C:15]3[C:11](=[CH:10][C:9]([C:3]([OH:8])([C:2]([F:1])([F:19])[F:20])[C:4]([F:7])([F:6])[F:5])=[CH:17][CH:16]=3)[CH2:12][CH:13]2[CH3:18])[N:32]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Komponenten

4

Edukt 3

HCID 210822102-Benzyl-4-chloromethyl-5-methyl-oxazoleHCID 233461261,1,1,3,3,3-hexafluoro-2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-propan-2-olHCID 737412221,1,1,3,3,3-hexafluoro-2-[2-methyl-1-(5-methyl-2-styryl-oxazol-4-ylmethyl)-2,3-dihydro-1H-indol-5-yl]-propan-2-ol

Produkt 1

HCID 210821742-[1-(2-benzyl-5-methyl-oxazol-4-ylmethyl)-2-methyl-2,3-dihydro-1H-indol-5-yl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

Versuchsvorschrift

In analogy to example 75.2, from 1,1,1,3,3,3-hexafluoro-2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-propan-2-ol (example 51.1) and 2-benzyl-4-chloromethyl-5-methyl-oxazole was prepared 1,1,1,3,3,3-hexafluoro-2-[2-methyl-1-(5-methyl-2-styryl-oxazol-4-ylmethyl)-2,3-dihydro-1H-indol-5-yl]-propan-2-ol, red oil, MS: 485 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-dc64358dec85419586cf6c9b6c2d4662
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07485652B2

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