1-Aminopiperidine → HCID 11548208, compound

HRID 1724059Notes

Reaction equation

[Br:1][C:2]1[S:24][C:5]2[CH2:6][CH2:7][C:8]3[C:9]([C:21](O)=[O:22])=[N:10][N:11]([C:13]4[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=4[Cl:20])[C:12]=3[C:4]=2[CH:3]=1.[NH2:25][N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[N:26]1([NH:25][C:21]([C:9]2[C:8]3[CH2:7][CH2:6][C:5]4[S:24][C:2]([Br:1])=[CH:3][C:4]=4[C:12]=3[N:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:10]=2)=[O:22])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

Reactant 2

HCID 166581-Aminopiperidine

HCID 11604687HCID 11604687, compound

Product 1

HCID 11548208HCID 11548208, compoundYield 42%

Procedure

The same procedure described in the preparations a) and b) of Example 3.1. was used to react the 7-bromo-1-(2′,4′-dichlorophenyl)-4,5-dihydro-1H-thieno[2,3-g]indazol-3-carboxylic acid prepared in the Example 2.2 with 1-aminopiperidine. The purification by flash chromatography (oil ether/ethyl acetate 6/4) has given the compound N-piperidinyl-7-bromo-1-(2′,4′-dichlorophenyl)-4,5-dihydro-1H-thieno[2,3-g]indazol-3-carboxamide as white solid with a 42% yield. Rf=0.33 (oil ether/ethyl acetate 6/4); m.p.: 145° C.;

Workup

customThe purification by flash chromatography (oil ether/ethyl acetate 6/4)

Sources & evidence

ORD record: ord-5a53dcfbab3542a3866f3cb60947898e
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07485730B2

Reaction notes

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