Acetic Anhydride → N-[(3S)-Tetrahydro-2,5-dioxo-3-furanyl]acetamide

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of N-Acetyl-L-aspartic acid (35.0 g, 199.9 mmol) in acetic anhydride (100 mL, 1.06 mol) was heated to 80° C. for ˜1 h until all the solid material had dissolved. The heating bath was removed, and the reaction mixture was stirred 4 h at ambient temperature. The product was collected by filtration and washed with tert-butyl methyl ether to afford N-acetyl-L-aspartic anhydride (27.8 g, 88%) as white crystals, [α]D−49.0° (c=2.5, Ac2O).

Provenance & Evidence