Lithium Hydroxide → HCID 16086934, compound

Participants

Reaction Steps

Compound 20b (443 mg, 0.552 mmol) in THF (14 ml) is treated with an aqueous solution of LiOH (0.5 M, 3.31 ml, 1.66 mmol) in accordance with the production of compound 2a. 343 mg (80%) of the desired dicarboxylic acid 2b are obtained as a colorless resin. IR (KBr) 3030, 2890, 2820, 2640, 2520, 1700, 1655, 1575 cm−1; 1H-NMR (CDCl3) δ 8.08 (d, 8.6 Hz, 2H), 8.01 (d, 8.4 Hz, 2H), 7.29 (d, 8.4 Hz, 2H), 7.10 (d, 8.6 Hz, 2H), 6.05 (t, 1.9 Hz, 1H), 6.02 (d, 1.9 Hz, 2H), 5.01 (s, 2H), 3.92-3.83 (m, 6H) 2.16 (t, 7.4 Hz, 2H), 1.80-1.62 (m, 8H), 1.49-1.21 (m, 30H), 0.87 (t, 6.7 Hz, 6H); MS (FD) m/z (%) 774 (M+). Anal. calc. for C47H67NO8: C, 72.93; H, 8.72; N, 1.81. Found C, 72.65; H, 8.77; N, 1.77.

Provenance & Evidence