HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-[(4-Chlorophenyl)(3-{2-fluoro-1-[3-fluoro-5-(4H-1,2,4-triazol-4-yl)phenyl]-2-methylpropyl}azetidin-1-yl)methyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-[Bromo(4-chlorophenyl)methyl]benzonitrile | HCID 67055351 | — |
| Reactant | HCID 67065977 | HCID 67065977 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[(4-Chlorophenyl)(3-{2-fluoro-1-[3-fluoro-5-(4H-1,2,4-triazol-4-yl)phenyl]-2-methylpropyl}azetidin-1-yl)methyl]benzonitrile | HCID 11420999 | — |
Reaction Steps
A sample of 135 mg (0.41 mmole) of 4-[3-(1-Azetidin-3-yl-2-fluoro-2-methylpropyl)-5-fluorophenyl]-4H-1,2,4-triazole hydrochloride, 211 mg (0.62 mmole) of 3-[bromo(4-chlorophenyl)methyl]benzonitrile and 181 uL (1.025 mmole) of diisopropylethylamine in 5 mL of dry CH3CN was heated at reflux for 3 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07485732B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-57bd896e7de84a6d9440e9e02aa4f6ff |
| Source note | uspto-grants-2009_02 |