HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinecarboxaldehyde → 2-[3-[(Z)-[(E)-(3-methyl-1,3-benzothiazol-2-ylidene)hydrazinylidene]methyl]pyridin-1-ium-1-yl]ethanol bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Reactant | Ethanol, 1-bromo- | HCID 14202443 | — |
| Reactant | (E)-3-methyl-N-(pyridin-3-ylmethylideneamino)-1,3-benzothiazol-2-imine | HCID 87882106 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[3-[(Z)-[(E)-(3-methyl-1,3-benzothiazol-2-ylidene)hydrazinylidene]methyl]pyridin-1-ium-1-yl]ethanol bromide | HCID 87674072 | — |
Reaction Steps
1.21 g (4.51 mmol) of nicotine aldehyde ((2E)-3-methyl-1,3-benzothiazol-2(3H)-ylidene hydrazone from Step 1 and 0.85 g (6.76 mmol) of bromoethanol in acetonitrile were heated at reflux for 2 hours. After the solvent was removed, the precipitate was suction-filtered off, washed with ethyl acetate and dried under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07488353B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-3e6ee7708e93420a809ba01ad8980809 |
| Source note | uspto-grants-2009_02 |