Tributylstannane → HCID 67260097, compound

Participants

Reaction Steps

To a solution of 1e (80 mg, 0.21 mmol) in anhydrous tetrahydrofuran (12.5 ml) under argon is added 2,2′-azobisisobutyronitrile (AIBN) (38 mg, 0.23 mmol) followed by tributyltin hydride (215 μl, 0.78 mmol). The reaction solution is placed in an 80° C. bath, refluxed 3.5 h, and evaporated to a solid. This material is purified by preparative TLC (Analtech GF, 10×20 cm, 1,000μ) with 9:1 CHCl3/MeOH as solvent. Pure 1f crystallized in two crops from acetonitrile as a white solid.

Provenance & Evidence